Thalidomide-O-PEG4-azide

Thalidomide-O-PEG4-Azide is a PEG4-linked thalidomide derivative containing an azide functional group. It consists of a thalidomide moiety connected through a tetraethylene glycol (PEG4) linker to a terminal azide group. The azide group provides a versatile handle for click chemistry, particularly copper-catalyzed azide–alkyne cycloaddition (CuAAC), enabling the compound to be conjugated with alkyne-functionalized molecules.

This compound can be used as a CRBN ligand building block for the synthesis of PROTACs (Proteolysis-Targeting Chimeras) and other targeted protein-degradation molecules. The PEG4 linker provides flexible spacing between the thalidomide/CRBN-binding moiety and the target-binding ligand.

IUPAC Name: 4-((14-azido-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Formula: C₂₃H₂₉N₅O₉
Molecular Weight: 519.5 g/mol
CAS No.: 2380318-57-8