免疫调节肽RP-182/1895883-60-9/RP-182

Product Name：RP-182

CAS No.：1895883-60-9

Synonyms：免疫调节肽RP-182

Catalog No.：220P418

Brand：Typeptide Biotech（肽研生物）

Description：RP-182是一种合成的免疫调节肽，是由10个氨基酸组成的多肽，通过靶向肿瘤相关巨噬细胞 (TAM) 表面的甘露糖受体 CD206 发挥抗肿瘤作用 (Kd = 8 μM)。RP-182 可诱导 CD206 受体的构象转换，从而激活 CD206 高表达 TAM 中的 NF-κB 信号转导和吞噬作用。RP-182 具有双重功能：激活经典 NF-κB 信号转导，触发 TNFα 分泌和 TNF 受体 1 (TNFR1) 的自分泌激活，从而导致 caspase 8 激活和细胞凋亡 (apoptosis)。RP-182 用于胰腺癌和黑色素瘤的研究。

RP-182 is a synthetic immunomodulatory peptide composed of 10 amino acids that exerts antitumor effects by targeting the mannose receptor CD206 on the surface of tumor-associated macrophages (TAMs) (Kd = 8 μM). RP-182 induces conformational changes in the CD206 receptor, thereby activating NF-κB signaling and phagocytosis in TAMs highly expressing CD206. RP-182 has dual functions: activating the classical NF-κB signaling pathway, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to caspase 8 activation and apoptosis. RP-182 is used in research on pancreatic cancer and melanoma.

Purity (HPLC) ≥98.0%

Single impurity≤2%

Peptide content≥75.0%

Amino Acid Composition≤±15%

Bacterial Endotoxins≤50EU/mg

Solubility：H₂O/DMSO

Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.

Storage:Cool dry place( Store at -20°C, away from the light)

Remark:For Research Use Only. Not for human use.

订购联系方式：

南京肽研生物生物科技有限公司

手机号：19961912513(微信同号)

QQ: 2178255659

邮箱：sales@typeptide.com

联系人：顾经理

申明：本产品仅供科研使用，不得用于人体。