PROTAC MDM2 Degrader-3

PROTAC MDM2 Degrader-3 is a proteolysis-targeting chimera (PROTAC) designed to promote targeted degradation of mouse double minute 2 homolog (MDM2), an important negative regulator of the tumor suppressor protein p53. The chemical name of PROTAC MDM2 Degrader-3 is ((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-(4-((4S,5R)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetate). By facilitating targeted protein degradation, this compound can be used to investigate MDM2-related signaling and p53-dependent cellular responses through the ubiquitin–proteasome pathway.

PROTAC MDM2 Degrader-3 has a CAS No. of 2249750-23-8, a molecular formula of C₇₂H₇₈Cl₄N₈O₁₅, and a molecular weight of 1437.25 g/mol. It is intended for research applications involving MDM2 degradation, p53 signaling, targeted protein degradation, PROTAC technology, cancer biology, apoptosis, and cell proliferation studies. The compound can serve as a research tool for studying MDM2–p53 pathway regulation and the biological effects associated with targeted MDM2 depletion. For research use only.