PROTAC STING Degrader-1

PROTAC STING Degrader-1 is a proteolysis-targeting chimera (PROTAC) designed for targeted degradation of Stimulator of Interferon Genes (STING), also known as TMEM173. The compound contains an E3 ubiquitin ligase-recruiting moiety connected to a STING-targeting ligand through a linker, facilitating the formation of a ternary complex and promoting ubiquitination and subsequent degradation of STING through the ubiquitin–proteasome system. The chemical name of PROTAC STING Degrader-1 is N1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-N4-(4-(5-nitrofuran-2-carboxamido)phenyl)fumaramide.

PROTAC STING Degrader-1 has a CAS No. of 2762552-74-7, a molecular formula of C₃₄H₃₃N₇O₁₀, and a molecular weight of 699.67 g/mol. It is intended for research applications involving STING signaling, targeted protein degradation, innate immune signaling, and immunology research. The compound can be used as a research tool for investigating STING-dependent cellular pathways and the biological consequences of targeted STING degradation. For research use only.