MC-Val-Cit-PAB-PROTAC ERα Degrader-1

MC-Val-Cit-PAB-PROTAC ERα Degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to promote targeted degradation of estrogen receptor alpha (ERα). It contains an ERα-targeting ligand and an E3 ubiquitin ligase-recruiting moiety connected by a linker, facilitating the formation of a ternary complex and promoting ERα ubiquitination followed by degradation through the ubiquitin–proteasome system. The chemical name of MC-Val-Cit-PAB-PROTAC ERα Degrader-1 is 4-((2S,3S)-8-cyano-5-((2-methoxynaphthalen-1-yl)methyl)-2-methyl-3-((S)-2-(methylamino)propanamido)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-1-carbonyl)-N-(2-(2-(2-((2-(4-((Z)-1-(4-((4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl)oxy)phenyl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)-2-oxoethoxy)ethoxy)ethyl)benzamide.

MC-Val-Cit-PAB-PROTAC ERα Degrader-1 has a CAS No. of 2158322-33-7, a molecular formula of C₉₄H₁₀₇N₁₃O₁₆, and a molecular weight of 1674.93 g/mol. It is intended for research applications involving ERα signaling, targeted protein degradation, PROTAC technology, and cancer biology. The compound may be used as a research tool for studying estrogen receptor-dependent pathways and ERα-related mechanisms, particularly in estrogen receptor-positive breast cancer models. For research use only.