PROTAC AR Degrader-8

PROTAC AR Degrader-8 is a proteolysis-targeting chimera (PROTAC) designed to induce targeted degradation of the androgen receptor (AR) through the ubiquitin–proteasome system. The chemical name of PROTAC AR Degrader-8 is 2-(2,6-dioxopiperidin-3-yl)-4-((2-(4-(2-(4-((3-(morpholin-2-yl)pyridin-2-yl)methoxy)phenyl)propan-2-yl)phenoxy)ethyl)amino)isoindoline-1,3-dione. Its CAS No. is 3044108-04-2, with a molecular formula of C₄₀H₄₁N₅O₇ and a molecular weight of 703.78 g/mol.

PROTAC AR Degrader-8 is intended for research applications involving androgen receptor signaling, targeted protein degradation, PROTAC technology, and prostate cancer biology. By promoting selective AR degradation, it can be used as a research tool for investigating AR-dependent cellular pathways and mechanisms associated with AR-driven cancers, including castration-resistant prostate cancer (CRPC). For research use only. Appropriate laboratory safety procedures should be followed during handling, preparation, and storage.