PROTAC EGFR degrader 11

PROTAC EGFR Degrader 11 is a small-molecule proteolysis-targeting chimera (PROTAC) designed for research involving targeted degradation of the epidermal growth factor receptor (EGFR). The compound is intended for studies of EGFR-related signaling pathways, targeted protein degradation (TPD), cancer biology, and drug discovery. Its PROTAC design incorporates a target-binding ligand and an E3 ligase-recruiting moiety to facilitate selective protein degradation through the ubiquitin–proteasome system.

Product Specifications: Chemical name: N-(2-((5-chloro-2-((4-(4-(4-(2-((1-(4-(2,6-dioxopiperidin-3-yl)-3-fluorophenyl)piperidin-4-yl)oxy)ethyl)piperazin-1-yl)piperidin-1-yl)-5-ethyl-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)-5-methoxyphenyl)-N-methylmethanesulfonamide. The compound is supplied as a solid and is intended for laboratory research applications. Store at −20°C in a dry, dark place. Keep the container tightly closed and protect from moisture and excessive light. Prepared solutions should preferably be aliquoted to minimize repeated freeze–thaw cycles.