PROTAC FAK degrader 1

PROTAC FAK Degrader 1 is a small-molecule proteolysis-targeting chimera (PROTAC) designed to selectively induce degradation of focal adhesion kinase (FAK). Also known as Compound PROTAC-3, it is intended for research involving targeted protein degradation, FAK signaling, cancer biology, and drug discovery. The compound has demonstrated effective FAK degradation in experimental models and can be used for studies investigating tumor cell migration, invasion, and FAK-associated signaling pathways.

Product Specifications: Chemical name: (2S,4R)-1-((S)-3,3-dimethyl-2-(3-(2-(4-((4-((3-(N-methylmethylsulfonamido)benzyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenoxy)ethoxy)propanamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CAS No. 2301916-69-6; molecular formula C₄₇H₅₆F₃N₉O₈S₂; molecular weight 996.13 g/mol; purity ≥98%. The compound is soluble in DMSO. Store at −20°C under nitrogen. Prepared solutions can be stored at −80°C for up to 6 months or −20°C for up to 1 month under nitrogen.

Precautions: This product is intended for research use only (RUO) . Handle in accordance with appropriate laboratory safety procedures. Minimize exposure to moisture and air during storage, and avoid unnecessary repeated freeze–thaw cycles of prepared solutions. Experimental conditions should be optimized according to the specific research application.