L(+)-2-氨基-4-膦酰基丁酸-L-150

一、产品概述

二、产品信息

L-APB; L-(+)-2-Amino-4-phosphonobutyric acid;A Potent and Selective Agonist of Group III mGluRs;L-AP4 (#L-150) is a highly pure, synthetic, and biologically active compound.

三、背景

L-AP4 is a synthetic, potent and selective agonist of group III metabotropic glutamate receptors (mGluR4 and mGluR6 through mGluR8). L-AP4 also depresses basal synaptic transmission in rat hippocampal slices with an IC50 of 3 µM in a dose dependent manner. Maximum depression of 74% is obtained at a concentration of 100 µM L-AP4. A concentration of 10 µM L-AP4 induces a depression of 59% and when the mGluR antagonist MCCG is added it shows little or no effect. In contrary, the mGluR antagonists MPPG and MTPG are effective L-AP4 antagonists1.
L-AP4-sensitive neuronal glutamatergic pathways include synapses of the mossy-fiber/ CA3 projection synapses of pyramidal cell projecting from the lateral olfactory tract to the pyriform cortex and synaptic contacts in the basolateral amygdala. It has also been suggested that L-AP4 sensitive receptors are important for memory and learning and might be implicated in the pathogenesis of Alzheimer’s disease2.

四、制备和贮存

五、产品特点

六、注意事项