PLK1 重组兔单克隆抗体 (S-2835-32)-S0B6446

PLK1 (Polo-like kinase 1) is a 603-residue serine/threonine kinase that peaks in late G2/M where it docks to phosphorylated Bub1 and the PBD-binding p-T78 motif on its own T-loop to auto-activate, then successively phosphorylates Cdc25C, Cyclin B1, Wee1, APC/C-Cdc20, and myriad kinetochore proteins to drive centrosome maturation, bipolar spindle assembly, chromosome alignment, the spindle-assembly and decatenation checkpoints, and timely mitotic exit, while its deregulated overexpression in cancers creates chromosomal instability and chemoresistance, making it a high-priority drug target whose ATP-competitive inhibitors (BI 2536, volasertib) are already in oncology trials.