PRMT5 重组兔单克隆抗体 (S-2336-126)-S0B6308

PRMT5 (protein arginine methyltransferase 5) is an evolutionarily conserved type II methyltransferase that catalyzes the symmetric dimethylation of arginine residues (SDMA) on histones H3R8me2s and H4R3me2s and on a broad spectrum of non-histone substrates including Sm proteins, RNA-binding proteins and transcription factors, thereby orchestrating chromatin remodeling, spliceosome assembly, transcriptional repression, signal transduction and stem-cell pluripotency; it functions as a tetrameric complex with MEP50, localizes to both cytoplasm and nucleus, exhibits oncogenic addiction in cancers such as mantle cell lymphoma and glioblastoma through its control of methionine and serine metabolism, and is targeted by potent, selective small-molecule inhibitors currently in clinical trials for tumors harboring MTAP deletions.