核纤层蛋白 B1 重组小鼠单克隆抗体 (S-4865)-S0B1853

Lamin B1 is a crucial type V intermediate filament protein and a major structural component of the nuclear lamina, a dense fibrillar network located on the inner side of the inner nuclear membrane in eukaryotic cells. Unlike its counterparts Lamin A and C, which are developmentally regulated and often absent in early embryonic stages or certain cell types, Lamin B1 is ubiquitously expressed and considered essential for cell viability, playing indispensable roles in maintaining nuclear shape, mechanical stability, and the spatial organization of chromatin. It serves as a scaffold for anchoring chromatin to the nuclear periphery, thereby influencing gene regulation, DNA replication, and repair processes, while also interacting with various integral membrane proteins to ensure proper nuclear envelope integrity during interphase and facilitating the disassembly and reassembly of the nuclear envelope during mitosis; consequently, dysregulation or mutations in the LMNB1 gene have been linked to severe neurological disorders, such as adult-onset autosomal dominant leukodystrophy, highlighting its critical importance in both cellular architecture and human health.