(S,R,S)-AHPC-PEG4-acid

(S,R,S)-AHPC-PEG4-acid is a synthetic PROTAC ligand and E3 ligase ligand-linker conjugate designed for targeted protein degradation research. It incorporates an AHPC-based E3 ligase-binding moiety connected to a flexible PEG4 spacer and a terminal carboxylic acid group. The PEG4 linker provides additional molecular flexibility and can facilitate the connection of the E3 ligase ligand to a protein-targeting ligand during PROTAC design and synthesis.

The chemical name of (S,R,S)-AHPC-PEG4-acid is 3-(2-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)ethoxy)propanoic acid. It has a CAS No. of 2172820-12-9, molecular formula C₃₄H₅₀N₄O₁₀S, and molecular weight 706.85 g/mol. The terminal carboxylic acid provides a useful reactive site for coupling with amine-containing molecules, making it suitable as a building block for the synthesis of heterobifunctional PROTAC molecules.

(S,R,S)-AHPC-PEG4-acid can be used in medicinal chemistry, chemical biology, and targeted protein degradation studies. By incorporating an E3 ligase ligand and PEG4 spacer into a PROTAC architecture, researchers can investigate molecules designed to recruit the cellular ubiquitin-proteasome system for selective protein degradation and support the development of targeted protein degradation technologies.