FKBP12 PROTAC dTAG-7

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional PROTAC degrader designed to selectively induce degradation of FKBP12^F36V-tagged proteins. It functions by simultaneously engaging the FKBP12^F36V target and the E3 ubiquitin ligase Cereblon (CRBN), facilitating formation of a ternary complex and promoting ubiquitination and subsequent degradation through the ubiquitin–proteasome system. dTAG-7 can be used as a chemical biology tool for rapid and selective degradation of engineered target proteins and for studying protein function.

The chemical name of FKBP12 PROTAC dTAG-7 is (1R)-3-(3,4-dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate. FKBP12 PROTAC dTAG-7 has a CAS No. of 2064175-32-0, a molecular formula of C₆₃H₇₉N₅O₁₉, and a molecular weight of 1210.32 g/mol.

FKBP12 PROTAC dTAG-7 is suitable for research applications involving targeted protein degradation, PROTAC technology, FKBP12^F36V degrader systems, CRBN-mediated degradation, and functional studies of engineered target proteins. The dTAG system has been used to study degradation of proteins including BRD4, HDAC1, EZH2, MYC, PLK1, and KRAS^G12V. For research use only.