PROTAC eEF2K degrader-1

PROTAC eEF2K Degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to promote targeted degradation of eukaryotic elongation factor 2 kinase (eEF2K/EEF2K), a kinase involved in the regulation of protein translation and cellular stress responses. The compound contains an eEF2K-targeting moiety linked to an E3 ubiquitin ligase-recruiting component through a flexible linker, facilitating formation of a ternary complex and promoting ubiquitination and subsequent degradation of eEF2K through the ubiquitin–proteasome system. The chemical name of PROTAC eEF2K Degrader-1 is 7-amino-3-(2-((2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethyl)amino)-2-oxoethyl)-1-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide.

PROTAC eEF2K Degrader-1 has a CAS No. of 2458170-54-0, a molecular formula of C₃₁H₃₃N₉O₁₁, and a molecular weight of 707.65 g/mol. It is intended for research applications involving eEF2K degradation, targeted protein degradation, PROTAC technology, protein translation, cellular signaling, cancer biology, and tumor research. The compound can be used as a research tool for investigating eEF2K-dependent pathways and the biological effects associated with targeted depletion of eEF2K. For research use only.