PROTAC HPK1 Degrader-1

PROTAC HPK1 Degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to induce targeted degradation of hematopoietic progenitor kinase 1 (HPK1), also known as MAP4K1. HPK1 is an intracellular kinase involved in the regulation of T-cell and other immune-cell signaling pathways and has attracted interest as a potential target in cancer immunotherapy. The chemical name of PROTAC HPK1 Degrader-1 is 4-((2-(3-(4-(4-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)-3-oxopropoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione. The compound is designed to facilitate recruitment of an E3 ubiquitin ligase to HPK1, promoting ubiquitination and subsequent degradation of the target protein through the ubiquitin–proteasome system.

PROTAC HPK1 Degrader-1 has a CAS No. of 3034182-97-0, a molecular formula of C₄₃H₄₃N₇O₈, and a molecular weight of 785.84 g/mol. It is intended for research applications involving HPK1/MAP4K1 degradation, targeted protein degradation, PROTAC technology, T-cell signaling, immune regulation, cancer immunotherapy, and tumor biology. The compound can be used as a research tool for investigating HPK1-dependent signaling pathways and the biological effects of targeted HPK1 depletion. For research use only.