重组人 Claudin18 蛋白(CLDN18.2, Nanodisc, Full Length, Avi & His Tag), Avi-tag Biotinylated

Recombinant Human Claudin18 Protein (Nanodisc, Full-length, Avi & His Tag), Biotinylated

￥10480 20µg 起订

￥18880 100µg 起订

北京更新日期：2026-08-31

北京义翘神州科技股份有限公司

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产品详情:

中文名称：: 重组人克劳丁-18 蛋白 (纳米盘, 全长, Avi & His 标签)，生物素标记

英文名称：: Recombinant Human Claudin18 Protein (Nanodisc, Full-length, Avi & His Tag), Biotinylated

品牌：: 义翘神州

产地：: 北京

保存条件：: -70℃

纯度规格：: 85 % SDS-PAGE

产品类别：: 膜蛋白

货号：: 30025-H73H-NA-B

规格：: 20.00 µg,100.00 µg

是否进口：: 否

靶点：: CLDN18

种属：: Human

表达系统：: HEK293 Cells

Recombinant Human Claudin18 Protein (CLDN18.2, Nanodisc, Full Length, Avi & His Tag), Avi‑tag Biotinylated

Cat No: 30025‑H73H‑NA‑B｜Official product page: https://cn.sinobiological.com/recombinant-proteins/human-claudin18-30025-h73h-na-b

Specifications

Purity

≥ 85 % as determined by SDS‑PAGE.

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Protein Construction

A DNA sequence encoding the human CLDN18.2 isoform (P56856‑2) (Met1‑Val261) was expressed with N‑terminal Avi‑tag and C‑terminal polyhistidine tag. The protein was biotinylated at Avi‑tag and prepared using our Nanodisc platform.

Accession #

P56856‑2

Expression Host

HEK293 Cells

Species

Human

30025 shot.png

Alternate Names

CLDN18 Claudin‑18.2

Background

Claudins family member Claudin18 (CLDN18) is a four‑pass transmembrane protein with two extracellular loops and cytoplasmic N‑ and C‑tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide‑expressing metaplasia (SPEM), and asthma. Lung‑specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF‑1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa‑specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR‑therapies currently in development.

Documents available on official page: Datasheet, COA, MSDS, Protocol, Reference citations.

CLDN18;全长CLDN18膜蛋白;CLDN18膜蛋白;CLDN18蛋白;人CLDN18蛋白;

公司简介

北京义翘神州科技股份有限公司作为国家高新技术企业，主要从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务，同时也为制药公司或者生物技术公司提供单克隆抗体候选药物的临床前规模生产服务。义翘神州拥有多项先进的核心技术以及从研发生产到放大生产的技术平台，为重组蛋白或者抗体试剂的高通量、高效率研发生产提供保障，旨在为全球制药企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。北京义翘神州是入选科技部"现代服务创新发展示范企业"的唯一的一家生物技术企业，是北京市民营企业科技创新百强，获批北京市单克隆抗体技术重点实验室，多次承担国家科技部重大新药创制专项、863科技攻关项目和北京市科委项目。

成立日期	(10年)
注册资本	12163.6742万人民币
员工人数	500人以上
年营业额	￥ 5000万-1亿
经营模式	试剂,定制,服务
主营行业	生化试剂,抗体,癌症研究,分子生物学,细胞生物学