102690-88-0 | Bis(2-cyanoethyl)-N,N-diisopropyl phosphoramidite | Oligonucleotide Synthesis Reagent | DNA/RNA Phosphoramidite Building Block

High-purity phosphoramidite reagent used in solid-phase oligonucleotide synthesis for DNA/RNA and siRNA/ASO drug development.

用于寡核苷酸（DNA/RNA/siRNA/ASO）合成的关键亚磷酰胺试剂，是核酸药物产业链核心基础原料之一。

Bis(2-cyanoethyl)-N,N-diisopropyl phosphoramidite 

CAS: 102690-88-0

Molecular Formula: C12H22N3O2P

Molecular Weight: 271.30

Appearance: Light yellow oily liquid

Purity: ≥98%

Grade: Oligonucleotide synthesis grade

Storage: -20°C, inert gas protection

Applications 应用领域

• Oligonucleotide synthesis (DNA/RNA oligo)

• siRNA drug development

• ASO (antisense oligonucleotide)

• mRNA / RNA therapeutics

• Probe & primer synthesis

• Gene therapy research 

Technical Advantages 技术优势

• High purity suitable for oligonucleotide coupling efficiency

• Ultra-low moisture content (<0.05% preferred)

• Low phosphine oxide impurity

• Strict anhydrous and oxygen-free manufacturing control

• Nitrogen-filled packaging available

• Stable batch-to-batch consistency

Supply Capability 供应能力

• Available from gram to kilogram scale

• Custom packaging under nitrogen protection

• Fast delivery for regular specifications

• OEM / bulk supply available for CDMO customers

Mechanism of Use 使用原理

This phosphoramidite reacts under tetrazole activation with hydroxyl groups during solid-phase oligonucleotide synthesis, forming a phosphite triester intermediate, which is subsequently oxidized to stable phosphate linkage.

The cyanoethyl protecting groups are removed under ammonolysis conditions.

We specialize in supplying high-purity oligonucleotide building blocks for RNA drug development companies worldwide.