首页
个人中心
委托采购
采购清单

网站主页化工产品目录生物蛋白与多肽重组蛋白 ERBB-2 重组人受体酪氨酸蛋白激酶 erbB-2蛋白 (His标签)

1/3

重组Her2/ERBB2蛋白(ECD, His Tag), HPLC-verified

Recombinant Human HER2 / ErbB2 Protein (His Tag)

￥580 10µg 起订

￥3310 100µg 起订

￥21520 1mg 起订

北京更新日期：2026-08-31

北京义翘神州科技股份有限公司

非会员

高新技术企业

联系人：义翘小助手

电话：400-890-9989拨打

手机：15201568907 拨打

邮箱：marketing@sinobiological.com

产品详情:

中文名称：: 重组人受体酪氨酸蛋白激酶 erbB-2蛋白 (His标签)

英文名称：: Recombinant Human HER2 / ErbB2 Protein (His Tag)

品牌：: 义翘神州

产地：: 北京

保存条件：: -20℃ to -80℃

纯度规格：: 90 % SDS-PAGE; 90 % SEC-HPLC; 90 % SEC-MALS

产品类别：: 药物靶点

货号：: 10004-H08H

规格：: 10.00 µg,100.00 µg,1.00 mg

是否进口：: 否

靶点：: ERBB2

种属：: Human

表达系统：: HEK293 Cells

Recombinant Human Her2/ERBB2 Protein (ECD, His Tag), HPLC‑verified

Cat No: 10004‑H08H｜Official product page: https://www.sinobiological.com/recombinant‑proteins/human‑her2‑erbb2‑10004‑h08h

Specifications

Purity

≥ 90 % as determined by SDS‑PAGE. ≥ 90 % as determined by SEC‑HPLC. ≥ 90 % as determined by SEC‑MALS(Routinely tested).

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Protein Construction

A DNA sequence encoding the extracellular domain (Met 1‑Thr 652) of human ErbB2 (NP_004439.2) was fused with the polyhistidine tag at the C‑terminus.

Accession #

NP_004439.2

Expression Host

HEK293 Cells

Species

Human

Predicted N Terminal

Thr 23

Molecule Mass

The recombinant human ErbB2 comprises 641 amino acids and has a calculated molecular mass of 71 kDa. As a result of glycosylation, rh ErbB2 migrates as an approximately 100‑110 kDa protein in SDS‑PAGE under reducing conditions. The molecular weight of this protein is around 87.5 kDa verified by SEC‑MALS (Routinely tested).

Formulation

Lyophilized from sterile PBS, pH 7.4. Normally 5 % ‑ 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.

Shipping

Lyophilized powder shipped at ambient temperature; Bulk frozen liquid shipped with blue ice.

Stability & Storage

Stable for up to twelve months from date of receipt at ‑20℃ to ‑80℃. Aliquot protein, avoid repeated freeze‑thaw cycles.

Activity

Immobilized protein can bind Anti‑HER2(Research Grade Trastuzumab biosimilar), EC₅₀:0.5‑2ng/mL (QC tested).
Neutralization ED₅₀:0.2‑1 μg/mL (Routinely tested).
SPR affinity:3.270 nM & 3.727 nM (Biacore T200, Routinely tested).
BLI affinity:0.382 nM & 0.547 nM (Octet RED384, Routinely tested).
Immobilized protein can bind Anti‑HER2 (Pertuzumab biosimilar), EC₅₀:0.9‑4ng/mL (Routinely tested).

Alternate Names

c‑ERB‑2 CD340 HER‑2/neu p185(erbB2)

Background

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand‑bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase‑mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Documents available on official page: Datasheet, COA, MSDS, Protocol, Reference citations.

HER-2;HER2;ERBB2;HER2蛋白;ERBB2蛋白;

公司简介

北京义翘神州科技股份有限公司作为国家高新技术企业，主要从事生物试剂研发、生产、销售并提供技术服务的生物科技公司，主要业务包括重组蛋白、抗体、基因和培养基等产品，以及重组蛋白、抗体的开发和生物分析检测等服务，同时也为制药公司或者生物技术公司提供单克隆抗体候选药物的临床前规模生产服务。义翘神州拥有多项先进的核心技术以及从研发生产到放大生产的技术平台，为重组蛋白或者抗体试剂的高通量、高效率研发生产提供保障，旨在为全球制药企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。北京义翘神州是入选科技部"现代服务创新发展示范企业"的唯一的一家生物技术企业，是北京市民营企业科技创新百强，获批北京市单克隆抗体技术重点实验室，多次承担国家科技部重大新药创制专项、863科技攻关项目和北京市科委项目。

成立日期	(10年)
注册资本	12163.6742万人民币
员工人数	500人以上
年营业额	￥ 5000万-1亿
经营模式	试剂,定制,服务
主营行业	生化试剂,抗体,癌症研究,分子生物学,细胞生物学