重组人R-脊椎蛋白-1蛋白

Recombinant Human R‑Spondin 1 / RSPO1 Protein

Cat No: 11083‑HNAS｜Official product page:        https://cn.sinobiological.com/recombinant-proteins/human-rspo1-11083-hnas

Specifications

Alternate Names

Background

RSPO1 gene is a member of the R‑spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein‑rich, furin‑like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy‑induced adverse effects. This protein is an activator of the beta‑catenin signaling cascade, leading to TCF‑dependent gene activation. RSPO1 acts both in the canonical Wnt/beta‑catenin‑dependent pathway and in non‑canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.