(2S,3S)-3-甲基氧杂环丁烷-2-羧酸

(2S,3S)-3-甲基氧杂环丁烷-2-羧酸（英文名：(2S,3S)-3-Methyloxetane-2-carboxylic acid，CAS号：3110040-83-7）是一种重要的手性药物中间体。其分子式为C₅H₈O₃，分子量为116.12。该化合物结构上包含一个四元环的氧杂环丁烷骨架，并在第2位和第3位碳上分别带有羧基和甲基，且具有明确的双手性中心（2S,3S构型）。

作为关键的结构单元，它主要用于合成RAS抑制剂RMC-5127等高价值药物，在靶向抗癌药物研发中具有重要应用。其关键优势在于可通过高对映选择性合成工艺获得，手性纯度（ee值）可达到99%以上，能有效保证下游药物合成的光学纯度和产品质量

(2S,3S)-3-Methyloxetane-2-carboxylic acid (English name: (2S,3S)-3-Methyloxetane-2-carboxylic acid, CAS No.: 3110040-83-7) is an important chiral pharmaceutical intermediate. Its molecular formula is C₅H₈O₃, with a molecular weight of 116.12. The compound structurally contains a four-membered oxetane ring skeleton, bearing a carboxyl group and a methyl group at the C-2 and C-3 positions, respectively, and possesses two defined chiral centers (2S,3S configuration).

As a key building block, it is primarily used in the synthesis of high-value drugs such as the RAS inhibitor RMC-5127, and has significant applications in targeted anticancer drug development. Its key advantage lies in its accessibility via highly enantioselective synthetic processes, achieving chiral purity (ee value) of over 99%, which effectively ensures the optical purity and product quality in downstream pharmaceutical synthesis.