人高灵敏白细胞介素12p70(IL-12p70)ELISA试剂盒

人高灵敏白细胞介素12p70(IL-12p70)ELISA试剂盒

货号:LM8K4932H

规格:48T/96T

种属:Human

范围:7.8-500pg/ml

灵敏度:4.6pg/ml

用途:For quantitative detection of IL-12 p70 in serum, plasma, tissue homogenates and otherbiological fluids.

存储:2-8°C 

截止日期: see kit label

原理:Sandwich

注意:仅供研究使用。

Background

IL-12 (interleukin 12) was first described as natural killer stimulating factor in 1989. The heterodimericcytokine IL-12 consists of a 35-kd light chain (p35 or IL-12A) and 40-kd heavy chain (p40 or IL-12B). The geneencoding p35 is located on chromosome 3 in human beings and on chromosome 6 in mice. The p35 proteincontains 197 amino acids and has homology to other single-chain cytokines (eg, IL-6 and G-CSF). The IL-12p40 gene is on the human chromosome 5 in the same area as IL-3, IL-5, and GM-CSF, and the mice gene is onchromosome 11. P40 has homology to the extracellular domain of members of hematopoietic cytokinereceptor family (eg, IL-6Rα). IL-12 (interleukin 12) receptor, binding interleukin 12, is composed of twosubunits, IL-12RB1 (also known as CD212) and IL12RB2. These IL-12 functions depend on its IL-12 and IL-12receptor complex.

IL-12 (interleukin 12) is a heterodimeric pro-inflammatory cytokine that induces the production ofinterferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and forms a link between innateresistance and adaptive immunity.

Dendritic cells (DCs) and phagocytes produce IL-12 in response to pathogens during infection. Production ofIL-12 is dependent on differential mechanisms of regulation of expression of the genes encoding IL-12,patterns of Toll-like receptor (TLR) expression and cross-regulation between the different DC subsets,involving cytokines such as IL-10 and type I IFN.

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