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网站主页 PKC NU, HUMAN, 重组蛋白 (GST) PKC nu, Human, 重组蛋白 (GST)
  • PKC nu, Human, 重组蛋白 (GST)|TMPY-04456|TargetMol

PKC nu, Human, 重组蛋白 (GST)|TMPY-04456|TargetMol

PKC nu Protein, Human, Recombinant (GST)
￥2530 50μg 起订
上海 更新日期：2026-05-11

TargetMol 中国（陶术生物）

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产品详情:

中文名称：
PKC nu, Human, 重组蛋白 (GST)
英文名称：
PKC nu Protein, Human, Recombinant (GST)
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature Store at -80°C
产品类别：
抑制剂
种属：
Human
表达系统：
Baculovirus Insect Cells
蛋白长度：
A DNA sequence encoding the full length of human PRKD3 (NP_005804.1) (Met 1-Pro 890) was expressed with the GST tag at the N-terminus. Predicted N terminal: Met
标签：
N-GST
货号：
T011|TMPY-04456

Product Introduction

Bioactivity

名称PKC nu Protein, Human, Recombinant (GST)
描述Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD3 / PRKCN contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. They also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. PRKD3 / PRKCN converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. It is involved in resistance to oxidative stress. PRKD3 / PRKCN is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain. PRKD3 / PRKCN can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. PRKD3 / PRKCN can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C gamma and the involvement of other PKC family members.
存储条件Store at low temperature Store at -80°C
关键字PKD-3 | PKD 3 | EPK-2 | EPK 2
protein kinase D3;PRKCN;PKD3;PKC-NU;nPKC-NU;EPK2;TargetMol

公司简介


成立日期 (14年)
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