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网站主页 GDF-10, MOUSE, 重组蛋白 (HFC) GDF-10, Mouse, 重组蛋白 (hFc)
  • GDF-10, Mouse, 重组蛋白 (hFc)|TMPY-01817|TargetMol

GDF-10, Mouse, 重组蛋白 (hFc)|TMPY-01817|TargetMol

GDF-10 Protein, Mouse, Recombinant (hFc)
￥6290 100μg 起订
上海 更新日期：2026-05-09

TargetMol 中国（陶术生物）

VIP1年
联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
GDF-10, Mouse, 重组蛋白 (hFc)
英文名称：
GDF-10 Protein, Mouse, Recombinant (hFc)
品牌：
TargetMol
产地：
美国
保存条件：
Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
产品类别：
抑制剂
种属：
Mouse
表达系统：
HEK293 Cells
蛋白长度：
A DNA sequence encoding the mature form of mouse GDF10 (NP_665684.2) (Gln 367-Arg 476) was fused with the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu 20
标签：
N-hFc
货号：
T011|TMPY-01817

Product Introduction

Bioactivity

名称GDF-10 Protein, Mouse, Recombinant (hFc)
描述BMP-3b / GDF-10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. In the bone morphogenetic cascade, cartilage differentiation, hypertrophy, and cell death are followed by bone formation. In this regard, all BMPs are cartilage morphogenetic proteins since cartilage is formed first. An overexpression or dysregulation of BMP pathways may lead to heterotopic bone formation or fibrodysplasia ossificans progressiva (FOP). BMPs have been implicated in FOP. The pioneering work of Sakou has implicated BMP-3b / GDF-10 in ossification of the posterior longitudinal ligament of the spine in Japanese patients. The BMP-specific antagonists such as noggin or chordin might be used therapeutically in clinical conditions with pathologically excessive bone formation. The osteoinductive capacity of BMPs has been demonstrated in preclinical models, and the efficacy of BMPs for the treatment of orthopaedic patients is now being evaluated in clinical trials. It was suggested that further progress in the clinical application of the BMP-3b / GDF-10 will depend upon the development of carriers with ideal release kinetics for the delivery of the BMPs.
存储条件Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
growth differentiation factor 10;Bmp3b;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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