替度鲁肽

Teduglutide是一种人胰高血糖素样肽-2 (GLP-2) 的类似物多肽，是由33个氨基酸组成的多肽。Teduglutide可以激活人肝星状细胞中的核受体亚家族 4 组 a 成员 1 (NR4a1)/nur77 表达和肠道 FXR 信号传导，从而改善硬化性胆管炎小鼠的肝脏炎症和纤维化。Teduglutide还可以缓解小鼠的肠功能不全，改善肺损伤，改善肥胖相关神经炎症和细胞凋亡 (apoptosis)。

Teduglutide is a peptide analogue of human glucagon like peptide-2 (GLP-2), consisting of 33 amino acids. Teduglutide can activate the expression of nuclear receptor subfamily 4a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can also alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and apoptosis.