HET-0016,20-HETESYNTHASE抑制剂

N'-(4-丁基-2-甲基苯基)-N-羟基甲脒;N-(4-丁基-2-甲基苯基)-N'-羟基甲基亚氨基酰胺;N-羟基-N'-(4-正丁基-2-甲基苯基)甲IDINE;化合物T11556;化合物HET0016;HET-0016,20-HETESYNTHASE抑制剂

HET0016;N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE;N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE;N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine;N-(4-buChemicalbooktyl-2-methylphenyl)-N'-hydroxyiminoformamide;N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide;Methanimidamide,N'-(4-butyl-2-methylphenyl)-N-hydroxy-;HET0016,HET-0016

熔点138-140°C储存条件Hygroscopic,-20°CFreezer,Underinertatmosphere溶解度可溶于氯仿（少许）、乙醇（少许）形态淡粉色固体。颜色白色至浅黄色InChI1S/C12H18N2O/c1-3-4-5-11-6-7-12(10Chemicalbook(2)8-11)13-9-14-15/h6-9,15H,3-5H2,1-2H3,(H,13,14)InChIKeyLYNOGBKNFIHKLE-UHFFFAOYSA-NSMILESCCCCC1=CC=C(C(C)=C1)/N=C/NOCAS数据库339068-25-6

用途HET-0016isapotentandselectiveinhibitorofthebiosynthesisof20-HETEactingviainhibitionofCYP4A(IC50=8.9nM(human),35nM(ratrenalmicrosome).IC50cyclooxygenase=2.3uM.IC50forotherCYP鈥檚:CYP2C9-3.3uM,CYP2D6=83.9uM,CYP3A4Chemicalbook=71uM.ItinhibitscerebrovascularconstrictioninducedbyCa2+orarchidonateandinhibitsangiogenesisandendothelialcellsproutinginvariousmodels.Displaysprotectiveeffectonbraindamageaftertemporaryfocalischemia(at10mg/Kg).