| 名称 | AB21 HCl |
| 描述 | AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity. |
| 体外活性 | AB21 HCL measured Ki values of 12 nM and 14 nM in the S1R radioligand binding assay with and without Phenythoin, respectively.[1] |
| 体内活性 | AB21 HCL (20 mg/kg; s.c.; administered 30 minutes before injection of Capsaicin reversed mechanical hypersensitivity in a Phenythoin-induced pain model and showed greater efficacy than BD1063 dihydrochloride higher potency, the dose administered was half that of BD-1063 (40 mg/kg).[1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 6.25 mg/mL (16.27 mM), Sonication is recommended.
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| 关键字 | σ2 | σ1 | Sigmareceptor | Sigma receptor | AB21HCL | AB21 HCl |
| 相关产品 | Glycerol phenylbutyrate | Amitriptyline hydrochloride | Sigma-1 receptor antagonist 1 | KSK67 | Cutamesine dihydrochloride | L-693,403 maleate | 4-PPBP maleate | Oxeladin citrate | Opipramol | Amitriptyline | S1R agonist 2 | Noscapine |
| 相关库 | 抑制剂库 | 经典已知活性库 | 抗癌化合物库 | 已知活性化合物库 | GPCR靶点分子库 | 多靶点化合物库 | 膜蛋白靶向化合物库 |
