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  • 化合物 NF-κB-IN-4|T60868|TargetMol

化合物 NF-κB-IN-4|T60868|TargetMol

NF-κB-IN-4
￥1120 2mg 起订
上海 更新日期：2026-05-09

TargetMol 中国（陶术生物）

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联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
化合物 NF-κB-IN-4
英文名称：
NF-κB-IN-4
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T60868

Product Introduction

Bioactivity

名称NF-κB-IN-4
描述NF-κB-IN-4 (compound 17) is a potent inhibitor of NF-κB pathway which can cross blood brain barrier (BBB). NF-κB-IN-4 shows potential anti-neuroinflammatory activity with low toxicity which can be used for the research of neuroinflammation related diseases. NF-κB-IN-4 can block the IκBα activation and phosphorylation, reduce NLRP3 expression, therefore inhibiting NF-κB activation [1].
体外活性NF-κB-IN-4 (compound 17) (0-10 μM, 24 h) shows high anti-inflammatory activity [1]. NF-κB-IN-4 (0-5 μM, 24 h) significantly decreases the LPS-induced p-IκBα expression levels, significantly inhibits the phosphorylation of IκBα and the expression of three proteins (NLRP3, ASC and caspase-1) in BV2 cells [1]. NF-κB-IN-4 (0-5 μM, 24 h) induces LPS-induced apoptosis in BV2 cells in a dose-dependent manner [1]. Cell Cytotoxicity Assay Cell Line: BV2 microglia cells [1] Concentration: 0, 2.5, 5, 10 μM Incubation Time: 24 h Result: Showed high anti-inflammatory activity, with the survival rate of BV2 microglia cells of 97.4%, inhibition rates against TNF-α and IL-6 release of 60.8% and 80.2%, respectively. Western Blot Analysis Cell Line: BV2 cells [1] Concentration: 0, 1.25, 2.5, 5 μM Incubation Time: 24 h Result: Significantly decreased the LPS-induced p-IκBα expression levels, significantly inhibited the phosphorylation of IκBα and the expression of three proteins (NLRP3, ASC and caspase-1) in BV2 cells. Apoptosis Analysis Cell Line: BV2 cells [1] Concentration: 0, 2.5, 5 μM Incubation Time: 24 h Result: Induced LPS-induced apoptosis in BV2 cells in a dose-dependent manner, with the apoptosis rates of 30.7% (2.5 μM) and 13.0% (5 μM), respectively.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
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NF-κB-IN-4|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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