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网站主页 β-D-Glucopyranose, cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate) cyclic 2→8:4→1-(2,3,3a,8b-tetrahydro-1,3,3a,5,6-pentahydroxy-1H-cyclopenta[b]benzofuran-1,8-dicarboxylate) 1-(3,4,5-trihydroxybenzoate) 叶下珠鞣质 C
  • 叶下珠鞣质 C|TN6623|TargetMol

叶下珠鞣质 C|TN6623|TargetMol

Phyllanthusiin C
￥1910 1mg 起订
￥4500 5mg 起订
上海 更新日期：2026-05-09

TargetMol 中国（陶术生物）

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产品详情:

中文名称：
叶下珠鞣质 C
英文名称：
Phyllanthusiin C
CAS号：
142674-52-0
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
97.56%
产品类别：
抑制剂
货号：
TN6623

Product Introduction

Bioactivity

名称Phyllanthusiin C
描述Phyllanthusiin C is a natural compound obtained from Phyllanthus reticulatus leaf red extract with antimicrobial activity and inhibits lipopolysaccharide (LPS)-induced nitric oxide production by IC cells RAW 264.7.
体外活性This study was designed to obtain the chemical fingerprint and to investigate the effect of Phyllanthus urinaria on telomerase activity and apoptotic pathways in the human nasopharyngeal carcinoma cell line (NPC-BM1). METHODS AND RESULTS: The polyphenol compounds in P. urinaria were investigated by HPLC/MS. Cell viability with the treatment of P. urinaria, gallic acid, ellagic acid, quercetin and cisplatin was detected by MTT assay. TUNEL assay, DNA fragmentation analysis and caspase3 activity were used to confirm apoptotic changes. Telomerase activity was determined using the TRAP assay. RNA isolation and RT-PCR were used to analyze the related genes expression. All experiments on treatments with P. urinaria from 0-3 mg/ml were carried out for 24 h. 5 major compounds including gallic acid, brevifolin carboxylic acid, corilagin, Phyllanthusiin C and ellagic acid were identified as a plant fingerprint by HPLC/MS. With the MTT assay, we demonstrated that P. urinaria, gallic acid and ellagic acid reduce cell viability. The apoptosis features showed DNA fragmentation and increased caspase-3 activity associated with the down-regulation of Bcl-2, but not of Bax, p53, and PCNA (proliferating cell nuclear antigen) in P. urinaria-treated NPC-BM1 cells. Furthermore, treatment of NPC-BM1 cells led to an inhibition of hTERT (human telomerase reverse transcriptase), hTP1 (human telomerase-associated protein 1) and c-myc mRNA expression and to decreased telomerase activity. CONCLUSIONS: This study suggests that P. urinaria induces the death of NPC-BM1 cells in vitro through the induction of apoptosis and inhibited telomerase activity.
存储条件Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
关键字Phyllanthusiin C
br
叶下珠鞣质 C|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

叶下珠鞣质 C相关厂家报价

  • 叶下珠粉
  • 叶下珠粉
  • 陕西新天域生物科技有限公司 VIP
  • 2026-05-11
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