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网站主页 PHGDH, HUMAN, 重组蛋白 (HIS) PHGDH, Human, 重组蛋白 (His)
  • PHGDH, Human, 重组蛋白 (His)|TMPY-02801|TargetMol

PHGDH, Human, 重组蛋白 (His)|TMPY-02801|TargetMol

PHGDH Protein, Human, Recombinant (His)
769 10μg 起订
上海 更新日期:2026-05-09

TargetMol 中国(陶术生物)

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产品详情:

中文名称:
PHGDH, Human, 重组蛋白 (His)
英文名称:
PHGDH Protein, Human, Recombinant (His)
品牌:
TargetMol
产地:
美国
保存条件:
Store at low temperature Store at -80°C
纯度规格:
96.00%
产品类别:
抑制剂
种属:
Human
表达系统:
E. coli
蛋白长度:
A DNA sequence encoding the mature form of human PHGDH (O43175) (Met 1-Phe 533) was fused with a polyhistidine tag at the C-terminus and an initial Met at the N-terminus. Predicted N terminal: Met
标签:
C-His
货号:
T011|TMPY-02801

Product Introduction

Bioactivity

名称PHGDH Protein, Human, Recombinant (His)
描述PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PHGDH catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor. Overexpression of PHGDH may cause certain breast cancers. Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency which is characterized by congenital microcephaly, psychomotor retardation, and seizures.
存储条件Store at low temperature Store at -80°C
关键字NLS-1 | NLS 1 | HEL-S113 | HEL-S 113
SERA;phosphoglycerate dehydrogenase;PHGDHD;PGDH;PGD;PGAD;PDG;NLS1;NLS;HEL-S-113;3-PGDH;3PGDH;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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