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网站主页 LCK, HUMAN, 重组蛋白 (HIS) Lck, Human, 重组蛋白 (His)
  • Lck, Human, 重组蛋白 (His)|TMPH-02275|TargetMol

Lck, Human, 重组蛋白 (His)|TMPH-02275|TargetMol

Lck Protein, Human, Recombinant (His)
￥11700 1mg 起订
上海 更新日期：2026-05-09

TargetMol 中国（陶术生物）

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电话：400-821-0310拨打
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邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
Lck, Human, 重组蛋白 (His)
英文名称：
Lck Protein, Human, Recombinant (His)
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
纯度规格：
90.00%
产品类别：
抑制剂
种属：
Human
表达系统：
E. coli
蛋白长度：
1-539 aa
标签：
N-6xHis
货号：
T011|TMPH-02275

Product Introduction

Bioactivity

名称Lck Protein, Human, Recombinant (His)
描述Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2.
存储条件Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字Protein YT 16 | LSK
Tyrosine-protein kinase Lck;T cell-specific protein-tyrosine kinase;Proto-oncogene Lck;Protein YT16;p56-LCK;Lymphocyte cell-specific protein-tyrosine kinase;Leukocyte C-terminal Src kinase (LSK);LCK;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

Lck, Human, 重组蛋白 (His)相关厂家报价

  • 重组蛋白
  • 重组蛋白
  • 爱必信（上海）生物科技有限公司 VIP
  • 2026-04-22
  • ￥1500
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