TWEAKR/TNFRSF12A, Human, 重组蛋白 (hFc)|TMPY-02757|TargetMol

TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)

￥22400 1mg 起订

上海更新日期：2026-05-09

TargetMol 中国（陶术生物）

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保存条件：: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months Shipping with blue ice/Shipping at ambient temperature.

名称	TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)
描述	Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. In response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro, the level of Fn14 is increased. A 1.2-kb FN14 transcript was expressed at high levels in heart, placenta, and kidney, at intermediate levels in lung, skeletal muscle, and pancreas, and at low levels in brain and liver. Also, elevated FN14 expression was found in human liver cancer cell lines and hepatocellular carcinoma specimens. Expression of mouse Fn14 was upregulated in hepatocellular carcinoma nodules that develop in 2 different transgenic mouse models of hepatocarcinogenesis. TNFRSF12A is the weak inducer of apoptosis in some cell types. It promotes angiogenesis and the proliferation of endothelial cells. TNFRSF12A may modulate cellular adhesion to matrix proteins.
存储条件	Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months Shipping with blue ice/Shipping at ambient temperature.
关键字	FN-14 \| FN 14 \| CD-266 \| CD 266

TWEAKR|||tumor necrosis factor receptor superfamily member 12A|||FN14|||CD266|TargetMol

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