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网站主页 化工产品目录 化学试剂 有机试剂 脂肪醇 22(S)-羟基胆固醇 22(S)-hydroxy Cholesterol
  • 22(S)-hydroxy Cholesterol|T36130|TargetMol

22(S)-hydroxy Cholesterol|T36130|TargetMol

22(S)-hydroxy Cholesterol
￥4230 10mg 起订
￥2380 5mg 起订
￥630 1mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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产品详情:

中文名称：
22(S)-hydroxy Cholesterol
英文名称：
22(S)-hydroxy Cholesterol
CAS号：
22348-64-7
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T36130

Product Introduction

Bioactivity

名称22(S)-hydroxy Cholesterol
描述22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度DMSO : 0.1 mg/mL (0.25 mM), Sonication is recommended.
DMF : 2 mg/mL (4.97 mM), Sonication is recommended.
Ethanol : 20 mg/mL (49.67 mM), Sonication is recommended.
Ethanol:PBS (pH 7.2)(1:2) : 0.3 mg/mL (0.75 mM), Sonication is recommended.
关键字22hydroxy Cholesterol | 22b-hydroxy Cholesterol | 22beta-hydroxy Cholesterol | 22(S)hydroxy Cholesterol | 22(S) hydroxy Cholesterol
相关产品Chlorpropamide | Acridone | Vigabatrin | Probucol | Isoxazole | GW6340 | Thiethylperazine dimaleate | SR 1903 | DIDS sodium salt | Prazosin hydrochloride | Vismodegib | Saikosaponin A
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22β-hydroxy Cholesterol|||22(S)-hydroxy Cholesterol|TargetMol

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成立日期 (14年)
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