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网站主页 C-ABL/ABL1, HUMAN, 重组蛋白 (GST) C-ABL/ABL1, Human, 重组蛋白 (GST)
  • C-ABL/ABL1, Human, 重组蛋白 (GST)|TMPY-04396|TargetMol

C-ABL/ABL1, Human, 重组蛋白 (GST)|TMPY-04396|TargetMol

C-ABL/ABL1 Protein, Human, Recombinant (GST)
￥5270 100μg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
C-ABL/ABL1, Human, 重组蛋白 (GST)
英文名称：
C-ABL/ABL1 Protein, Human, Recombinant (GST)
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature Store at -80°C
纯度规格：
90.90%
产品类别：
抑制剂
种属：
Human
表达系统：
Baculovirus Insect Cells
蛋白长度：
A DNA sequence encoding the amino acid sequence (Pro 137-Ser 554) of human ABL1 isoform B (NP_009297.2) was fused with the GST tag at the N-terminus. Predicted N terminal: Met
标签：
N-GST
货号：
T011|TMPY-04396

Product Introduction

Bioactivity

名称C-ABL/ABL1 Protein, Human, Recombinant (GST)
描述c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
存储条件Store at low temperature Store at -80°C
关键字JTK-7 | JTK 7
v-abl;p150;JTK7;c-ABL1;c-ABL;bcr/abl;ABL proto-oncogene 1, non-receptor tyrosine kinase;ABL;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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