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网站主页 ACID SPHINGOMYELINASE/SMPD1, MOUSE, 重组蛋白 (HIS) Acid sphingomyelinase/SMPD1, Mouse, 重组蛋白 (His)
  • Acid sphingomyelinase/SMPD1, Mouse, 重组蛋白 (His)|TMPY-02585|TargetMol

Acid sphingomyelinase/SMPD1, Mouse, 重组蛋白 (His)|TMPY-02585|TargetMol

Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
6530 100μg 起订
上海 更新日期:2026-05-08

TargetMol 中国(陶术生物)

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产品详情:

中文名称:
Acid sphingomyelinase/SMPD1, Mouse, 重组蛋白 (His)
英文名称:
Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
品牌:
TargetMol
产地:
美国
保存条件:
Store at low temperature Store at -80°C
纯度规格:
90.70%
产品类别:
抑制剂
种属:
Mouse
表达系统:
Baculovirus Insect Cells
蛋白长度:
A DNA sequence encoding the mouse SMPD1 (Q04519) (Met 1-Leu 626) was expressed,with a C-terminal polyhistidine tag. Predicted N terminal: Leu 45
标签:
C-His
货号:
T011|TMPY-02585

Product Introduction

Bioactivity

名称Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
描述Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monomeric lysosomal enzyme that converts sphingomyelin (a plasma membrane lipid ) into ceramide through the removal of phosphorylcholine. This generates second messenger components that participate in signal transduction. Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPA) and type B (NPB), also known as Niemann-Pick disease classical infantile form and Niemann-Pick disease visceral form. Niemann-Pick disease is a clinically and genetically heterogeneous recessive disorder. NPB has little if any neurologic involvement and patients may survive into adulthood.
存储条件Store at low temperature Store at -80°C
Zn-SMase;sphingomyelin phosphodiesterase 1;A-SMase;aSMase;ASM;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
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主营行业 天然产物,生物化工,化学试剂,生物技术服务

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