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网站主页 IKBKB, HUMAN, 重组蛋白 (HIS) IKBKB, Human, 重组蛋白 (His)
  • IKBKB, Human, 重组蛋白 (His)|TMPH-01531|TargetMol

IKBKB, Human, 重组蛋白 (His)|TMPH-01531|TargetMol

IKBKB Protein, Human, Recombinant (His)
￥1850 10μg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

VIP1年
联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
IKBKB, Human, 重组蛋白 (His)
英文名称：
IKBKB Protein, Human, Recombinant (His)
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
产品类别：
抑制剂
种属：
Human
表达系统：
Baculovirus Insect Cells
蛋白长度：
1-756 aa
标签：
N-10xHis
货号：
T011|TMPH-01531

Product Introduction

Bioactivity

名称IKBKB Protein, Human, Recombinant (His)
描述Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death. Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus.
存储条件Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字Nuclear factor NF-kappa-B inhibitor kinase β (NFKBIKB) | Nuclear factor NF-kappa-B inhibitor kinase b (NFKBIKB) | NFKBIKB | Inhibitor of nuclear factor kappa-B kinase subunit β | Inhibitor of nuclear factor kappa-B kinase subunit b | IKK-β | IKKβ | IKK-2 | IKK2 | I-kappa-B-kinase β | I-kappa-B-kinase b
Serine/threonine protein kinase IKBKB;Nuclear factor NF-kappa-B inhibitor kinase beta (NFKBIKB);Inhibitor of nuclear factor kappa-B kinase subunit beta;IKK-beta;IKK-B;IKKB;IkBKB;I-kappa-B-kinase beta;I-kappa-B kinase 2 (IKK-2;IKK2);TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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