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网站主页 MMP-1, HUMAN, 重组蛋白 (HIS) MMP-1, Human, 重组蛋白 (His)
  • MMP-1, Human, 重组蛋白 (His)|TMPY-00886|TargetMol

MMP-1, Human, 重组蛋白 (His)|TMPY-00886|TargetMol

MMP-1 Protein, Human, Recombinant (His)
33600 1mg 起订
上海 更新日期:2026-05-08

TargetMol 中国(陶术生物)

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产品详情:

中文名称:
MMP-1, Human, 重组蛋白 (His)
英文名称:
MMP-1 Protein, Human, Recombinant (His)
品牌:
TargetMol
产地:
美国
保存条件:
Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
产品类别:
抑制剂
重组:
种属:
Human
表达物种:
Human
蛋白长度:
A DNA sequence encoding the pro form of human MMP1 enzyme (NP_002412.1) precursor (Met 1-Asn 469) was expressed with a C-terminal polyhistidine tag. Predicted N terminal: Phe 20
标签:
C-His
修饰:
C-His
UniProt ID:
P03956
PubChem CID:
P03956
缓冲液:
Lyophilized from a solution filtered through a 0.22 μm filter, containing 25 mM MES, 10 mM CaCl2, 150 mM NaCl, 0.05% Brij 35, pH 5. 5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
表达系统:
HEK293 Cells
货号:
T011|TMPY-00886

Product Introduction

Bioactivity

名称MMP-1 Protein, Human, Recombinant (His)
描述MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defenses. Dysregulation of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis, and cancer. Tumour metastasis is a multistep process involving the dissemination of tumor cells from the primary tumor to secondary at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
存储条件Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
matrix metallopeptidase 1;CLGN;CLG;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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