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  • 帕立骨化醇|TQ0200|TargetMol

帕立骨化醇|TQ0200|TargetMol

Paricalcitol
￥1370 1mg 起订
￥3450 5mg 起订
￥4910 10mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
帕立骨化醇
英文名称：
Paricalcitol
CAS号：
131918-61-1
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
99.84%
产品类别：
抑制剂
货号：
TQ0200

Product Introduction

Bioactivity

名称Paricalcitol
描述Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
动物实验After TAC or sham surgery, a subset of the mice is treated with paricalcitol which activates the VDR, at a final dose of 300 ng/kg/day. Paricalcitol is dissolved in a 95% propylene glycol and 5% ethyl alcohol solution. Mice were intraperitoneally injected with paricalcitol (or vehicle only) three times per week on Monday, Wednesday, and Friday for five consecutive weeks. An established anti-hypertrophic and anti-fibrotic treatment, namely the angiotensin II receptor blocker (ARB) losartan is also included. Previous experiments have shown it is feasible and efficacious to dissolve losartan in the drinking water at a concentration of 30 mg/kg/day; mice are treated for five consecutive weeks. So, in total eight groups are studied. Sham (n=10), TAC (n=10), Sham + losartan (Sham-los, n=10), TAC + losartan (TAC-los, n=10), Sham + paricalcitol (Sham-pari, n=10), TAC + paricalcitol (TAC-pari, n=10), Sham + paricalcitol + losartan (Sham-combi, n=10) and TAC + paricalcitol + losartan (TAC-combi, n=10) [2].
体外活性Paricalcitol (30 nM; HP + PC) produces a significant reduction in calcification relative to the observed in cells in HP medium. Paricalcitol causes a reduction in the levels of nuclear β-catenin to a level similar to that observed in control cells [1].
体内活性Paricalcitol (300 ng/kg/day) significantly decreases Tau and prevents LV dysfunction in mice. It reduces mRNA expression of ANP, fibronectin and collagen III in the TAC-pari mice [2].
存储条件Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.
溶解度H2O : Insoluble
Ethanol : 12 mg/mL (28.8 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 3.3 mg/mL (7.92 mM), Sonication is recommended.
DMSO : 140 mg/mL (336.02 mM), Sonication is recommended.
关键字Vitamin D receptor | Vitamin D | VD/VDR | Paricalcitol | Inhibitor | inhibit
相关产品Phenindione | Retinyl acetate | Vitamin D2 | Warfarin sodium | Doxercalciferol | DL-Panthenol | Calcitriol | Biotin | 5,6-trans-Vitamin D3 | Calcipotriol monohydrate | Vitamin D3 | Phenprocoumon
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帕立骨化醇|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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