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网站主页 IRAK4, HUMAN, 重组蛋白 (HIS) IRAK4, Human, 重组蛋白 (His)
  • IRAK4, Human, 重组蛋白 (His)|TMPY-04483|TargetMol

IRAK4, Human, 重组蛋白 (His)|TMPY-04483|TargetMol

IRAK4 Protein, Human, Recombinant (His)
￥5610 100μg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

VIP1年
联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
IRAK4, Human, 重组蛋白 (His)
英文名称：
IRAK4 Protein, Human, Recombinant (His)
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature Store at -80°C
产品类别：
抑制剂
种属：
Human
表达系统：
Baculovirus Insect Cells
蛋白长度：
A DNA sequence encoding the full length of human IRAK4 (Q9NWZ3-1) (Met 1-Ser 460) was expressed with a polyhistidine tag at the N-terminus. Predicted N terminal: Met
标签：
N-His
货号：
T011|TMPY-04483

Product Introduction

Bioactivity

名称IRAK4 Protein, Human, Recombinant (His)
描述Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. It also phosphorylates IRAK1. A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. IL-1-mediated IRAK4 kinase activity in T cells is essential for the induction of IL-23R expression, Th17 differentiation, and autoimmune disease. Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defense while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
存储条件Store at low temperature Store at -80°C
关键字REN-64 | REN 64 | IRAK4 | IRAK 4 | IPD-1 | IPD 1
REN64;NY-REN-64;IRAK-4;IPD1;interleukin-1 receptor-associated kinase 4;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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