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网站主页 COAGULATION FACTOR XI/F11 , HUMAN, 重组蛋白 (HIS) Coagulation factor XI/F11 , Human, 重组蛋白 (His)
  • Coagulation factor XI/F11 , Human, 重组蛋白 (His)|TMPY-01104|TargetMol

Coagulation factor XI/F11 , Human, 重组蛋白 (His)|TMPY-01104|TargetMol

Coagulation factor XI/F11 Protein, Human, Recombinant (His)
￥4470 50μg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
Coagulation factor XI/F11 , Human, 重组蛋白 (His)
英文名称：
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
品牌：
TargetMol
产地：
美国
保存条件：
Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
纯度规格：
97.80%
产品类别：
抑制剂
种属：
Human
表达系统：
HEK293 Cells
蛋白长度：
A DNA sequence encoding the human F11 (NP_000119.1) precursor (Met 1-Val 625) with a carboxy-terminal polyhistidine tag was expressed. Predicted N terminal: Glu 19
标签：
C-His
货号：
T011|TMPY-01104

Product Introduction

Bioactivity

名称Coagulation factor XI/F11 Protein, Human, Recombinant (His)
描述Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide.
存储条件Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
FXI;coagulation factor XI;coagulation factor 11;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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