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网站主页 IKB ALPHA/NFKBIA, HUMAN, 重组蛋白 (HIS) IkB alpha/NFKBIA, Human, 重组蛋白 (His)
  • IkB alpha/NFKBIA, Human, 重组蛋白 (His)|TMPY-01710|TargetMol

IkB alpha/NFKBIA, Human, 重组蛋白 (His)|TMPY-01710|TargetMol

IkB alpha/NFKBIA Protein, Human, Recombinant (His)
￥697 5μg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

VIP1年
联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
IkB alpha/NFKBIA, Human, 重组蛋白 (His)
英文名称：
IkB alpha/NFKBIA Protein, Human, Recombinant (His)
品牌：
TargetMol
产地：
美国
保存条件：
Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
产品类别：
抑制剂
货号：
TMPY-01710

Product Introduction

Bioactivity

名称IkB alpha/NFKBIA Protein, Human, Recombinant (His)
描述Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper functioning. Signal-induced degradation of I kappa B alpha exposes the nuclear localization signal of NF-kappa B, thus allowing it to translocate into the nucleus and activate transcription from responsive genes. An autoregulatory loop is established when NF-kappa B induces expression of the I kappa B alpha gene and newly synthesized I kappa B alpha accumulates in the nucleus where it negatively regulates NF-kappa B-dependent transcription. As part of this post-induction repression, the nuclear export signal on I kappa B alpha mediates the transport of NF-kappa B-I kappa B alpha complexes from the nucleus to the cytoplasm. Deletion of NFKBIA has an effect that is similar to the effect of EGFR amplification in the pathogenesis of glioblastoma and is associated with comparatively short survival. Polymorphisms in NFKBIA may be important in pre-disposition to and outcome after treatment, of multiple myeloma (MM). The NFKBIA gene product, IkappaBalpha, binds to NF-kappaB preventing its activation and is important in mediating resistance to apoptosis in B-cell lymphoproliferative diseases.
存储条件Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字MAD3 | MAD 3
br
nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor, alpha|||nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, α|||nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha|||NFKBI|||MAD-3|||IKBA|||IkB α|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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