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  • 王不留行环肽 A|TN2200|TargetMol

王不留行环肽 A|TN2200|TargetMol

Segetalin A
￥745 1mg 起订
￥1820 5mg 起订
￥2690 10mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
王不留行环肽 A
英文名称：
Segetalin A
CAS号：
161875-97-4
品牌：
TargetMol
产地：
美国
保存条件：
Keep away from moistureKeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
99.83%
产品类别：
抑制剂
货号：
T008|TN2200

Product Introduction

Bioactivity

名称Segetalin A
描述Segetalin A is a cyclic peptide isolated from the seeds of Vaccaria hispanica; it belongs to the class of naturally occurring cyclic peptides of plant origin and exhibits weak cytotoxicity toward HEK293 cells.
体外活性Total methanolic extracts of Saponaria vaccaria seed derived from several varieties, as well as various purified components obtained through successive chromatographic separations of total extracts were evaluated for their growth inhibitory activity in WiDr (colon), MDA-MB-231 (breast), NCI-417 (lung) and PC-3 (prostate) human cancer cells as well as the non-tumorigenic fibroblast BJ (CRL-2522) cell line using MTT colorimetric assay. Purified bisdesmosidic saponins segetoside H and I were further examined using microscopy and apoptosis assays. Bisdesmosidic saponins exhibited dose-dependent growth inhibitory and selective apoptosis-inducing activity. Growth inhibitory effects were particularly strong in a breast (MDA-MB-231) and a prostate (PC-3) cancer cell line. Total extracts exhibited a different preference being most active against a colon cancer cell line (WiDr). In a comparison of varieties, all of the total seed extracts exhibited similar dose-dependent activities, but with some variation in potency. Monodesmosidic saponins vaccarosides A and B, phenolic vaccarin, and cyclopeptide Segetalin A, co-occurring seed substituents, did not exhibit activity. The non-tumorigenic fibroblast cell line BJ (CRL 2522) was growth inhibited but did not undergo apoptosis when treated with bisdesmosidic saponins at low micromolar concentrations.
存储条件Keep away from moistureKeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度Methanol : < 1?mg/mL?(insoluble), Sonication and heating are recommended.
关键字Segetalin A | progestogenReceptor | progestogen Receptor | EstrogenReceptor | Estrogen/progestogen Receptor | Estrogen Receptor/ERR | Estrogen Receptor
相关库中药单体化合物库 | 中国药典收录天然产物库 | 高通量筛选天然产物库
王不留行环肽 A;Vaccarin D;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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