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网站主页 MAPK3, HUMAN, 重组蛋白 (HIS) MAPK3, Human, 重组蛋白 (His)
  • MAPK3, Human, 重组蛋白 (His)|TMPH-01692|TargetMol

MAPK3, Human, 重组蛋白 (His)|TMPH-01692|TargetMol

MAPK3 Protein, Human, Recombinant (His)
￥11700 1mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
MAPK3, Human, 重组蛋白 (His)
英文名称：
MAPK3 Protein, Human, Recombinant (His)
品牌：
TargetMol
产地：
美国
保存条件：
Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
纯度规格：
90.00%
产品类别：
抑制剂
种属：
Human
表达系统：
E. coli
蛋白长度：
11-379 aa
标签：
N-6xHis
货号：
T011|TMPH-01692

Product Introduction

Bioactivity

名称MAPK3 Protein, Human, Recombinant (His)
描述Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
存储条件Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字PRKM 3 | p44-MAPK | p44MAPK | p44-ERK 1 | MAP kinase3 | ERT 2 | ERK-1 | ERK 1
PRKM3;p44-ERK1;Mitogen-activated protein kinase 3;Microtubule-associated protein 2 kinase;MAPK3;MAPK 3;MAP kinase isoform p44 (p44-MAPK);MAP kinase 3;Insulin-stimulated MAP2 kinase;Extracellular signal-regulated kinase 1 (ERK-1);ERT2;ERK1;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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