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网站主页 N-glycolyl-Ganglioside GM3 Mixture (ammonium salt) N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
  • N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)|T36413|TargetMol

N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)|T36413|TargetMol

N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
￥13000 500μg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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产品详情:

中文名称：
N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
英文名称：
N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
CAS号：
69345-49-9
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
产品类别：
抑制剂
货号：
T36413

Product Introduction

Bioactivity

名称N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
描述N-glycolyl-Ganglioside GM3(NeuGc-GM3) is a form of ganglioside GM3 that contains an N-glycolylated sialic acid (NeuGc).
体外活性It is not biosynthesized in humans under baseline conditions due to a mutation in CMP-Neu5Ac hydroxylase (CMAH), which converts N-acetyl sialic acid to N-glycolyl sialic acid, but NeuGc can be taken up by human cellsviathe diet and incorporated into glycolipids, such as ganglioside GM3.1,2NeuGc-GM3 impairs differentiation and maturation of dendritic cellsin vitroand reduces CD4 expression in non-activated T cells.1,3It increases the number of lung tumor nodules formed in a murine Lewis lung carcinoma model.4It is found in a variety of human cancers, including breast and lung cancers, as well as pediatric cancers.1Levels of NeuGc-GM3 are negatively correlated with the number of mature dendritic cells in patient-derived non-small cell lung cancer (NSCLC) tumor tissue.5Anti-NeuGc-GM3 antibodies, able to destroy tumor cells in vitro, have been found in individuals without cancer but not in patients with NSCLC.1,6N-glycolyl-Ganglioside GM3mixture contains ganglioside GM3molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths.
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
关键字N-glycolyl-Ganglioside GM-3 Mixture (ammonium salt) | NglycolylGanglioside GM3 Mixture (ammonium salt) | N-glycolyl-Ganglioside GM3 Mixture | N glycolyl Ganglioside GM3 Mixture (ammonium salt)
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N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)|TargetMol

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成立日期 (14年)
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