PAK-3, Human, 重组蛋白 (His)|TMPY-04397|TargetMol

PAK-3 Protein, Human, Recombinant (His)

￥1930 20μg 起订

上海更新日期：2026-05-08

TargetMol 中国（陶术生物）

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联系人：邵经理

电话：400-821-0310拨打

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邮箱：xuexiang.shao@tsbiochem.com

保存条件：: Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

蛋白长度：: A DNA sequence encoding the human PAK3 isoform 2 (O75914-2) (Met 1-Arg 544) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Met 1

名称	PAK-3 Protein, Human, Recombinant (His)
描述	PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group I p21-activated kinases (PAK1/2/3) is demonstrated as ERK3/ERK4 activation loop kinases. It has been shown that group I PAKs phosphorylate ERK3 and ERK4 on Ser-189 and Ser-186, respectively, both in vitro and in vivo, and that expression of activated Rac1 augments this response. Besides regulation enzymatic activation of ERK3/ERK4, PAKs can also play roles in downstream activation of MAP kinase-activated protein kinase 5 (MK5) in vivo. Thus, the group I PAKs act as upstream activators of ERK3 and ERK4 and unravel a novel PAK-ERK3/ERK4-MK5 signaling pathway. In clinical, PAK has been proposed as a potential therapeutic target in schwannomas.
存储条件	Store at low temperature Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months
关键字	OPHN-3 \| OPHN 3 \| MRX-47 \| MRX-30 \| MRX 47 \| MRX 30

PAK3β;PAK3beta;p21 protein (Cdc42/Rac)-activated kinase 3;OPHN3;MRX47;MRX30;hPAK3;CDKN1A;bPAK;TargetMol

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