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网站主页 IGF2/IGF-II, HUMAN, 重组蛋白 IGF2/IGF-II, Human, 重组蛋白
  • IGF2/IGF-II, Human, 重组蛋白|TMPY-00150|TargetMol

IGF2/IGF-II, Human, 重组蛋白|TMPY-00150|TargetMol

IGF2/IGF-II Protein, Human, Recombinant
￥12700 1mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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联系人：邵经理
电话：400-821-0310拨打
手机：15002144251 拨打
邮箱：xuexiang.shao@tsbiochem.com

产品详情:

中文名称：
IGF2/IGF-II, Human, 重组蛋白
英文名称：
IGF2/IGF-II Protein, Human, Recombinant
品牌：
TargetMol
产地：
美国
保存条件：
Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
纯度规格：
98.70%
产品类别：
抑制剂
种属：
Human
表达系统：
P. pastoris (Yeast)
蛋白长度：
A DNA sequence encoding the human IGF2 (P01344-1) (Ala25-Glu91) was expressed. Predicted N terminal: Ala 25
标签：
Tag Free
货号：
T011|TMPY-00150

Product Introduction

Bioactivity

名称IGF2/IGF-II Protein, Human, Recombinant
描述Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland. IGF-2 and exhibited statistically significant, positive associations with colorectal cancer risk when cases were confined to those diagnosed within a relatively short period after enrolment. Circulating IGF-2 and IGFBP-3 can serve as early indicators of impending colorectal cancer. IGF-2/IGF-II appears to be involved in the progression of many tumors. It binds to at least two different types of receptors: IGF type 1 (IGF 1R) and mannose 6-phosphate/IGF type 2 (M6-P/IGF 2R). Ligand binding to IGF 1R provokes mitogenic and anti-apoptotic effects. M6-P/IGF 2R has a tumor suppressor function—it mediates IGF 2 degradation. Mutation of M6-P/IGF 2R causes both diminished growth suppression and augmented growth stimulation. This study aimed to investigate the role of IGF 2 and its receptors (IGF 1R and IGF 2R) in human gastric cancer.
存储条件Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months
关键字PP-9974 | PP 9974
胰岛素样生长因子;PP9974;insulin-like growth factor 2;IGF-II;C11orf43;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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