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网站主页 化工产品目录 化学试剂 有机试剂 多环化合物 N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐 N-Desbutyl Dronedarone (hydrochloride)
  • N-Desbutyl Dronedarone (hydrochloride)|T35712|TargetMol

N-Desbutyl Dronedarone (hydrochloride)|T35712|TargetMol

Debutyldronedarone hydrochloride
￥975 1mg 起订
￥3900 5mg 起订
￥7320 10mg 起订
上海 更新日期：2026-05-08

TargetMol 中国（陶术生物）

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产品详情:

中文名称：
N-Desbutyl Dronedarone (hydrochloride)
英文名称：
Debutyldronedarone hydrochloride
CAS号：
197431-02-0
品牌：
TargetMol
产地：
美国
保存条件：
Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
纯度规格：
98%
产品类别：
抑制剂
货号：
T35712

Product Introduction

Bioactivity

名称Debutyldronedarone hydrochloride
描述N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 μM, respectively, in cell-free assays).2N-Desbutyl dronedarone decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50= 1.07 μM) and inhibits mitochondrial complex I, also known as NADH dehydrogenase, and mitochondrial complex II, also known as succinate dehydrogenase, activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 μM, respectively).3
存储条件Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度DMSO : 30 mg/mL (55.85 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (3.72 mM), Sonication is recommended.
DMSO:PBS (pH 7.2) (1:6) : 0.14 mg/mL (0.26 mM), Sonication is recommended.
DMF : 30 mg/mL (55.85 mM), Sonication is recommended.
Ethanol : 1 mg/mL (1.86 mM), Sonication is recommended.
关键字Debutyldronedarone hydrochloride
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br
SR35021 hydrochloride|TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ￥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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