Osteoprotegerin, Human, 重组蛋白 (aa 22-401, His)|TMPJ-01466|TargetMol

Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)

￥930 50μg 起订

上海更新日期：2026-05-08

TargetMol 中国（陶术生物）

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邮箱：xuexiang.shao@tsbiochem.com

保存条件：: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

名称	Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
描述	TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo. TNFRSF11B binding to RANKL on osteoblast/stromal cells, blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.
存储条件	Lyophilized powder: -20~-80°C for 1 year \| Solution: -80°C for 6 months

Tumor Necrosis Factor Receptor Superfamily Member 11B;TNFRSF11B;Osteoprotegerin;Osteoclastogenesis Inhibitory Factor;OPG;OCIF;TargetMol

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