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网站主页 HTRA2/OMI, HUMAN, 重组蛋白 (HIS) HtrA2/Omi, Human, 重组蛋白 (His)
  • HtrA2/Omi, Human, 重组蛋白 (His)|TMPY-02078|TargetMol

HtrA2/Omi, Human, 重组蛋白 (His)|TMPY-02078|TargetMol

HtrA2/Omi Protein, Human, Recombinant (His)
697 10μg 起订
上海 更新日期:2026-05-08

TargetMol 中国(陶术生物)

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产品详情:

中文名称:
HtrA2/Omi, Human, 重组蛋白 (His)
英文名称:
HtrA2/Omi Protein, Human, Recombinant (His)
品牌:
TargetMol
产地:
美国
保存条件:
Store at low temperature Store at -80°C
纯度规格:
88.00%
产品类别:
抑制剂
种属:
Human
表达系统:
E. coli
蛋白长度:
A DNA sequence encoding the mature form of human HTRA2 (O43464-1) (Ala 134-Glu 458) was expressed, with a polyhistide tag at the C-terminus. Predicted N terminal: Met
标签:
C-His
货号:
T011|TMPY-02078

Product Introduction

Bioactivity

名称HtrA2/Omi Protein, Human, Recombinant (His)
描述Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity or by a BIRC inhibition-independent, caspase-independent, and serine protease activity-dependent mechanism. HTRA2 cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 of HTRA2 seems to be proteolytically inactive. Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) which is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity, and postural instability, as well as by a clinically significant response to treatment with levodopa.
存储条件Store at low temperature Store at -80°C
关键字PRSS-25 | PRSS 25 | PARK-13 | PARK 13
PRSS25;PARK13;OMI;HtrA serine peptidase 2;TargetMol

公司简介


成立日期 (14年)
注册资本 589.8595万人民币
员工人数 100-500人
年营业额 ¥ 1亿以上
经营模式 贸易,工厂,试剂,定制,服务
主营行业 天然产物,生物化工,化学试剂,生物技术服务

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