化合物Protirelin Acetate

Protirelin Acetate(24305-27-9 free base)

￥193 1mg 起订

￥417 5mg 起订

￥598 10mg 起订

上海更新日期：2026-06-22

TargetMol中国（陶术生物）

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产品详情:

中文名称：: 化合物Protirelin Acetate

英文名称：: Protirelin Acetate(24305-27-9 free base)

CAS号：: 25575-91-1

品牌：: TargetMol

产地：: 美国

保存条件：: Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

纯度规格：: 98.78%

产品类别：: 抑制剂

货号：: T006|T6956L

Product Introduction

Bioactivity

名称	Protirelin Acetate(24305-27-9 free base)
描述	Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) is a tripeptide that stimulates the release of thyrotropin and prolactin.
动物实验	Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.
体内活性	Protirelin（TRH）是一种进化古老的神经肽，在原口动物和后口动物分化之前就已存在，可能原本涉及控制胚后生长和繁殖。研究探讨了下丘脑释放激素之一的促甲状腺激素释放激素（Protirelin, TRH）对大鼠体温的影响。向体重200-250克的雄性Wistar大鼠腹腔内注射1、5、10和20 mg/kg的Protirelin。结果显示，Protirelin能够依剂量暂时性地提高体温。而在接受20 mg/kg Protirelin注射的甲状腺切除大鼠中，相较于假手术动物引发显著的高热反应，体温却未见上升。当前结果表明，甲状腺激素的释放可能参与Protirelin的高热作用。
存储条件	Keep away from moisture Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
溶解度	DMSO : 27.5 mg/mL (65.1 mM), Sonication is recommended.
关键字	Thyroidhormonereceptor(THR) \| Thyroidhormonereceptor \| Thyroid hormone receptor(THR) \| Thyroid hormone receptor \| Thyroid hormone \| THR \| Protirelin Acetate(24305-27-9 free base) \| Protirelin Acetate(24305279 free base) \| Protirelin Acetate(24305 27 9 free base)
相关产品	L-Thyroxine sodium \| Iopanoic acid \| Azetirelin \| Carbimazole \| Methimazole \| Resmetirom \| PCO371 \| 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE \| DS08210767 \| Eneboparatide \| Octinoxate \| Tiratricol
相关库	NO PAINS 化合物库 \| FDA 上市药物库 \| 天然产物库 \| 高通量筛选天然产物库

TRH Acetate;TRF Acetate;Thyroliberin Acetate;Synthetic thyrotropin-releasing hormone Acetate;pGlu-His-Pro-NH2 Acetate;Lopremone Acetate;TargetMol

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	(14年)
注册资本	589.8595万人民币
员工人数	100-500人
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